MITOCHONDRIAL DIVISION INHIBITOR (MDIVI-1) INDUCES EXTRACELLULAR MATRIX (ECM)-DETACHMENT OF VIABLE BREAST CANCER CELLS BY A DRP1-INDEPENDENT MECHANISM

Abstract Increasing evidence supports the hypothesis that cancer progression is under mitochondrial control.Mitochondrial fission plays a pivotal role in the maintenance of cancer cell homeostasis.The inhibition of DRP1, the main Lower Clamp Cover regulator of mitochondrial fission, with the mitochondrial division inhibitor (mdivi-1) had been assoc

ZnO photocatalysts in water react with environmental water molecules and Horse Muzzles corrode under illumination.ZnO nanorods in water can also grow because of water splitting induced by UV irradiation.To investigate their morphological behavior caused by crystal growth and corrosion, here we developed a new laser-equipped high-voltage electron mi

Bacterial cultures, when under appropriate conditions, will grow into a biofilm.This weak hydrogel, composed of a complex conglomeration of bacterial clusters and extrapolymeric substances, serves to protect and insulate the bacteria from mechanical disturbances and environmental perturbations that may include antibiotics.Measuring the bulk rheolog

BACKGROUND: The choroid plexus epithelium (CPE) is a lobed neuro-epithelial structure that forms the outer blood-brain barrier.The CPE protrudes into the brain ventricles and produces the cerebrospinal fluid (CSF), which is crucial for brain homeostasis.Malfunction of the CPE is possibly implicated in disorders like Alzheimer disease, hydrocephalus

Candida albicans SC5314 is the most-often used strain for molecular manipulation of the species.The SC5314 reference genome sequence is the result of considerable effort from many scientists and has advanced research into fungal biology and pathogenesis.Although the resource is highly developed and presented in a phased diploid format, the sequence